Objectives\u00a0 <\/b>Periodontitis is an inflammatory disease caused by the formation of a bacterial biofilm that, espe\u00adcially in predisposed subjects, may lead to periodontal ligament destruction and alveolar bone re\u00adsorption.<\/p>\n
The aim of this work was to study the effectiveness of the treat\u00adment of intrabony defects due to periodontitis using bone granules and equine-derived pericardium membranes.<\/p>\n
Materials and methods\u00a0 <\/b>Clinical records of 22 patients who underwent regenerative therapy for intrabony defects fol\u00adlowing periodontitis at the au\u00adthor\u2019s dental center were retro\u00adspectively selected. Patients in\u00adcluded in this retrospective study a) had a single 1-, 2- or 3-walls intrabony defect; b) had a probing pocket depth (PPD) \u22655 mm after initial therapy; c) had good oral hygiene (mean plaque index – PI \u22641); d) were treated using an equine bone graft and equine pericardium membrane; e) were followed up for \u226512 months.<\/p>\n
According to the individual anat\u00adomy, access to the defect was achieved using either the modi\u00adfied papilla preservation tech\u00adnique (MPPT) or the simplified papilla preservation flap (SPPF) procedure.<\/p>\n
Defects were grafted using an equine bone graft, consisting of a 1:1 mixture of cortical-cancel\u00adlous granules sized 0.5-1 mm (Osteoxenon, Bioteck, Arcugna\u00adno, Vicenza, Italy) after hydrating them using sterile saline solution.<\/p>\n
A 25 x 25 x 0.2 mm pericardium membrane (Heart, Bioteck, Arcu\u00adgnano, Italy) was shaped, hydrat\u00aded, and positioned to protect the graft. Data extracted from clinical records included the patients\u2019 de\u00admographics (age and sex) and their smoking habits (non-smoker or smoked \u226410 cigarettes\/day).<\/p>\n
Clinical parameters of interest were the Probing Pocket Depth (PPD), the Clinical Attachment Level (CAL), the Plaque Index (PI), and the Sulcus Bleeding Index (SBI) recorded at baseline (before surgery) and at the 12, 24, and 60-months check-up appoint\u00adments. Complications and ad\u00adverse effects were also assessed.<\/p>\n
Results\u00a0 <\/b>Records were analyzed for 22 non-consecutive patients (12 men and 10 women) with a mean age of 59.0\u00b17.0 years (range from 47 to 77 years). All patients complet\u00aded the healing period following re\u00adgenerative surgery with no com\u00adplications or adverse events.<\/p>\n
The mean follow-up period was 60.1\u00b11.13 months. PI, SBI, PPD, and CAL values were significantly lower at all follow-up visits than at baseline (p <0.05 in all cases). At the final follow-up, the CAL gain was 4.8 mm, corresponding to 58% improvement compared to the pre-operative condition, and the PPD was 2.46\u00b10.50 mm. Starting from the 12-month check-up, the mean CAL re\u00admained constant. Additionally, starting from the 24-month check-up, the mean PPD did not show significative differences at the subsequent follow-up, indicating that bone resorption was absent or limited from that time onward.<\/p>\n
No correlations were observed at any time point between the mea\u00adsured parameters and the num\u00adber of walls of the periodontal de\u00adfect. There were no significant dif\u00adferences between smokers (\u226410 cigarettes\/day) and non-smokers patients at any time point, except for a difference in the SBI index at the 12-month follow-up visit.<\/p>\n
Conclusions\u00a0 <\/b>Equine bone granules plus equine pericardium membranes allowed safe and successful regenerative therapy of intrabony defects caused by periodontitis.<\/p>\n
Clinical significance\u00a0 <\/b>The results presented indicate that bone granules and equine-derived pericardium membranes are a safe and effective instru\u00adment for the clinician in the treat\u00adment of intrabony defects on a medium-term basis.<\/p>\n
Per continuare la lettura gli abbonati possono scaricare l’allegato.<\/i><\/p>\n
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