{"id":2001,"date":"2021-07-26T10:00:53","date_gmt":"2021-07-26T08:00:53","guid":{"rendered":"https:\/\/www.dentalcadmos.com\/importance-of-clinical-and-genetical-evaluation-for-non-syndromic-oligodontia-in-orthodontics\/"},"modified":"2021-07-26T10:00:53","modified_gmt":"2021-07-26T08:00:53","slug":"importance-of-clinical-and-genetical-evaluation-for-non-syndromic-oligodontia-in-orthodontics","status":"publish","type":"post","link":"https:\/\/www.dentalcadmos.com\/en\/importance-of-clinical-and-genetical-evaluation-for-non-syndromic-oligodontia-in-orthodontics\/","title":{"rendered":"Importance of clinical and genetical evaluation for non-syndromic oligodontia in orthodontics"},"content":{"rendered":"

Objectives  <\/b> Hypodontia is one of the most common congenital dental abnor\u00admalities. It affects approximately between the 2 to 10% of the gen\u00aderal population. It is frequently as\u00adsociated with other oral anoma\u00adlies, such as structural variations and malformations of other teeth, late eruption, transposition and crowding.<\/p>\n

The most commonly missing permanent teeth are the third molars (9-37%), followed by mandibular second premolars (<3%), maxillary lateral incisors (<2%) and maxillary second pre\u00admolars and mandibular incisors (<1%). More than 300 genes are involved in tooth development and the most common genes associ\u00adated with the hypodontia are: WN\u00adT10A, MSX1, PAX9 and AXIN2. WNT family member 10A, LDL re\u00adceptor-related protein 6, and WNT family member 10B are all impli\u00adcated in oligodontia phenotypes.<\/p>\n

Using whole-exome, novel and known variants in WNT pathway genes can be identified, and par\u00adticularly in WNT10A, as pathogen\u00adic for familiar oligodontia. The ob\u00adjective of this case report is to evaluate the importance of the treatment and diagnosis of oli\u00adgodontia in a healthy patient.<\/p>\n

Materials and methods  <\/b> A 14-year-old male patient at\u00adtended for an orthodontic con\u00adsultation. The clinical examina\u00adtion revealed missing of four third molars, four mandibular in\u00adcisors, two second lower premo\u00adlars and two second lower mo\u00adlars. Two lateral maxillary inci\u00adsors resulted microdontic.<\/p>\n

Fami\u00adly anamnesis did not reveal his\u00adtory of dental agenesis. The pa\u00adtient and his family were directed for a genetic consultation. Ortho\u00addontic treatment objectives were the alignment of the upper and lower dental arches, correction of positions of the central inci\u00adsors and manage the space for the restorative therapy of micro\u00addontic teeth and future implant and prosthodontic treatment.<\/p>\n

Results  <\/b>The genetic analyses find that par\u00adents of the patient and the patient himself have a mutation of WN\u00adT10A gene. As parents are carriers of the mutation there is a 50% risk that this mutation will be passed onto their son.<\/p>\n

Therefore, the pa\u00adtient is diagnosed with compatible oligodontia. The patient holds a risk of 100% of passing this muta\u00adtion to his children. Patient started his treatment with bonding of up\u00adper dental arch with a system cus\u00adtomized vestibular brackets and a prosthetic bite to give a support to lower arch and reduce overbite.<\/p>\n

After creating the space for micro\u00addontic lateral incisors, a conserva\u00adtive treatment was made on four superior incisors for make an aes\u00adthetics smile.<\/p>\n

Conclusions  <\/b> The patient with oligodontia gen\u00aderally suffer abnormal occlusion, difficulty in mastication and speech among with altered facial appearance which may cause psychological distress.<\/p>\n

A strong genetic link associated with oli\u00adgodontia helps the dentist to know the possibility of its occurrence in other family members and in fu\u00adture generations.<\/p>\n

Clinical significance  <\/b> It is fundamental to direct the patients affected by oligodontia to a genetic analysis and know the probability of passing the mutation to their children.<\/p>\n

Dental rehabilitation of patients with oli\u00adgodontia requires orthodontic, prosthodontic and conservative treatment at the appropriate time jointly by a paediatric den\u00adtist and other dental specialists to improve oral health and psy\u00adchological development of the child. <\/p>\n

Per continuare la lettura scaricare l’allegato.
<\/i><\/p>\n

doi: https:\/\/doi.org\/10.19256\/d.cadmos.08.2019.08<\/a><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

Objectives  Hypodontia is one of the most common congenital dental abnor\u00admalities. It affects approximately between the 2 to 10% of the gen\u00aderal population. It is frequently as\u00adsociated with other oral anoma\u00adlies, such as structural variations and malformations of other teeth, late eruption, transposition and crowding. The most commonly missing permanent teeth are the third molars … Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"yoast_head":"\nImportance of clinical and genetical evaluation for non-syndromic oligodontia in orthodontics - Dental Cadmos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dentalcadmos.com\/en\/importance-of-clinical-and-genetical-evaluation-for-non-syndromic-oligodontia-in-orthodontics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Importance of clinical and genetical evaluation for non-syndromic oligodontia in orthodontics - Dental Cadmos\" \/>\n<meta property=\"og:description\" content=\"Objectives  Hypodontia is one of the most common congenital dental abnor\u00admalities. 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