{"id":2330,"date":"2021-07-26T10:01:02","date_gmt":"2021-07-26T08:01:02","guid":{"rendered":"https:\/\/www.dentalcadmos.com\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/"},"modified":"2021-07-26T10:01:02","modified_gmt":"2021-07-26T08:01:02","slug":"saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer","status":"publish","type":"post","link":"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/","title":{"rendered":"Saliva 8-hydroxy-2\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer"},"content":{"rendered":"<div><b>Objectives&nbsp; <\/b>Radiotherapy is the most common treatment in patients suffering from head and neck cancers. The aim of this study was to evaluate the changes in 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG) levels &#8211; as a crucial biomarker of oxidative stress and carcinogenesis &#8211; in patients affected with head and neck squamous cell carcinoma (HNSCC) following radiotherapy.<\/div>\n<div><b>Materials and Method<\/b>s&nbsp; A cross-sectional study was carried out in 30 patients with HNSCC before and after radiotherapy, and in 30 healthy controls. The HNSCC were documented by two blinded expert pathologists. Whole saliva samples were collected and 8-OHdG levels were analysed by ELISA method.<\/div>\n<div><b>Results&nbsp; <\/b>The saliva levels of 8-OHdG (ng\/ mL) were significantly higher in patients with HNSCC before radiotherapy (502.2 \u00b1 48.0) than after radiotherapy (311.2 \u00b1 44.1) and control individuals (326.7 \u00b1 41.0) (p &lt; 0.05). There was no significant difference in saliva 8-OHdG between patients with HNSCC after radiotherapy and control individuals.<\/div>\n<div><b>Conclusions&nbsp; <\/b>It seems that saliva 8-OHdG levels return to normal range after radiotherapy in patients with HNSCC.<\/div>\n<div><\/div>\n<div><i>Per continuare la lettura scaricare l&#8217;allegato.<\/i><\/div>\n<div><\/div>\n<div><b>doi: <a href=\"https:\/\/doi.org\/10.19256\/d.cadmos.08.2016.07\">https:\/\/doi.org\/10.19256\/d.cadmos.08.2016.07<\/a><\/b><\/div>\n<div><\/p>\n<p><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Objectives&nbsp; Radiotherapy is the most common treatment in patients suffering from head and neck cancers. The aim of this study was to evaluate the changes in 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG) levels &#8211; as a crucial biomarker of oxidative stress and carcinogenesis &#8211; in patients affected with head and neck squamous cell carcinoma (HNSCC) following radiotherapy. Materials and &hellip; <a href=\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/\">Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Saliva 8-hydroxy-2\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer - Dental Cadmos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Saliva 8-hydroxy-2\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer - Dental Cadmos\" \/>\n<meta property=\"og:description\" content=\"Objectives&nbsp; Radiotherapy is the most common treatment in patients suffering from head and neck cancers. The aim of this study was to evaluate the changes in 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG) levels &#8211; as a crucial biomarker of oxidative stress and carcinogenesis &#8211; in patients affected with head and neck squamous cell carcinoma (HNSCC) following radiotherapy. Materials and &hellip; Continued\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Dental Cadmos\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-26T08:01:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Greta Schincaglia\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.dentalcadmos.com\/#website\",\"url\":\"https:\/\/www.dentalcadmos.com\/\",\"name\":\"Dental Cadmos\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.dentalcadmos.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/#webpage\",\"url\":\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/\",\"name\":\"Saliva 8-hydroxy-2\\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer - Dental Cadmos\",\"isPartOf\":{\"@id\":\"https:\/\/www.dentalcadmos.com\/#website\"},\"datePublished\":\"2021-07-26T08:01:02+00:00\",\"dateModified\":\"2021-07-26T08:01:02+00:00\",\"author\":{\"@id\":\"https:\/\/www.dentalcadmos.com\/#\/schema\/person\/03773f859d81b9eff9790a180b88dd5e\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.dentalcadmos.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Saliva 8-hydroxy-2\\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer\"}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.dentalcadmos.com\/#\/schema\/person\/03773f859d81b9eff9790a180b88dd5e\",\"name\":\"Greta Schincaglia\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.dentalcadmos.com\/#personlogo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/5d4eda3c3873680e78bca07f48f82b5d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/5d4eda3c3873680e78bca07f48f82b5d?s=96&d=mm&r=g\",\"caption\":\"Greta Schincaglia\"},\"url\":\"https:\/\/www.dentalcadmos.com\/en\/author\/almaware\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Saliva 8-hydroxy-2\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer - Dental Cadmos","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.dentalcadmos.com\/en\/saliva-8-hydroxy-2-deoxyguanosine-changes-following-radiotherapy-in-patients-with-head-and-neck-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Saliva 8-hydroxy-2\u2019-deoxyguanosine changes following radiotherapy in patients with head and neck cancer - Dental Cadmos","og_description":"Objectives&nbsp; Radiotherapy is the most common treatment in patients suffering from head and neck cancers. 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